PW02-019 - Inflammatory pathways activation in TRAPS patients
نویسندگان
چکیده
Methods To understand the complexity of intracellular signalling pathway perturbation in TRAPS, a prototypic mutant TNFR1 (C33Y), or wild-type TNFR1 (WT), were expressed at near physiological levels in an SK-Hep-1 cell model system. TNFR1-associated signalling pathway intermediates were examined under a range of conditions, employing reverse-phase protein microarray. Peripheral blood mononuclear cells (PBMC) from C33Y TRAPS patients and matched healthy controls were similarly examined.
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Altered cytokine pattern and inflammatory pathways in monogenic and complex autoinflammatory diseases
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